The BSE benchmark Sensex fell 152.69 factors or 0.31 per cent to 49,472.07 in early commerce on Friday, monitoring subdued Asian markets.
Likewise, the broader NSE Nifty dropped 54.35 factors or 0.37 per cent to 14,590.35 in opening commerce.
On the Sensex chart, Axis Bank, Tech Mahindra, ONGC, Dr Reddy’s, Bajaj Finance and Sun Pharma had been main laggards.
Bajaj Auto, Asian Paints, Mahindra and Mahindra, Maruti Suzuki and Reliance Industries had been prime gainers.
On Thursday, the Sensex had dropped 167.36 factors or 0.34 per cent to finish at 49,624.76, and the Nifty had shed 54.35 factors or 0.37 per cent to shut at 14,590.35.
Intra-day, the 30-share BSE Sensex had touched the 50,000-level for the primary time ever on Thursday on development optimism and world cues however succumbed to profit-booking in fag-end commerce.
Asian shares had been buying and selling broadly decrease in late afternoon offers on Friday, a day after hitting report highs.
Foreign institutional traders remained internet patrons within the capital market as they bought shares value Rs 1,614.66 crore on Thursday, in response to alternate information.
The world oil benchmark Brent crude slipped 1.37 per cent to USD 55.40 per barrel.