COVID-19 vaccine race: Where they stand presently

Image Source : PTI COVID-19 vaccine race: Where they stand presently
Almost a yr into the COVID-19 pandemic, about 200 vaccine candidates are within the works and 10 have been both accepted by a number of international locations or are below restricted emergency use. As India prepares to launch its vaccine drive on January 16, here’s a have a look at the choices:

COVAXIN

Developed by Bharat Biotech in collaboration with the Indian Council of Medical Research and the National Institute of Virology, the indigenous vaccine was granted emergency use authorisation in ‘clinical trial mode’ by the Indian authorities this week.
It is an “inactivated” vaccine developed by chemically treating novel coronavirus samples to make them incapable of copy. This course of leaves the viral proteins, together with the spike protein of the coronavirus which it makes use of to enter the human cells, intact. 
Given as two doses, three weeks aside, the viral proteins within the vaccine activate the immune system and put together individuals for future infections with the precise infectious virus. According to Bharat Biotech, the therapeutic might be saved at room temperature for at the very least every week.
A research on the Phase 1/2 trial revealed within the preprint server medRxiv in December confirmed the therapeutic does not trigger any severe uncomfortable side effects.
However, there was no additional knowledge launched within the public area which might reveal that the vaccine is secure and efficient.
“ICMR-Bharat Biotech vaccine is a killed whole-virus vaccine and there are absolutely no data available so far on its protective efficacy. I am critical of its getting approval by the authorities,” immunologist Vineeta Bal, affiliated with the National Institute of Immunology in New Delhi, informed PTI.
COVISHIELD

Co-developed by the University of Oxford and British-Swedish firm AstraZeneca and generally known as Covishield in India, the vaccine was the primary on which a scientific research was revealed primarily based on Phase 3 scientific trials. It has thus far been given emergency use authorization within the UK, Argentina, Mexico and India.
Scientists have engineered a model of adenoviruses that infect chimpanzees to hold the gene liable for the spike protein of the novel coronavirus.
It requires two doses, offered 4 weeks aside, to supply the specified results.
Manufactured by the Serum Institute of India, Covishield will likely be bought at Rs 1,000 per dose within the personal market however price the Indian authorities solely Rs 200, stated SII CEO Adar Poonawalla,
“Oxford-AstraZeneca-Serum Institute vaccine has shown protective efficacy in global trials to the tune of 60-70 per cent. While clear data from bridging trials in India are not available, the vaccine is certainly proven safe,” Bal stated.
According to virologist Upasana Ray from the CSIR-Indian Institute of Chemical Biology, Kolkata, the AstraZeneca-Oxford vaccine is much less restricted by way of chilly storage as it may be saved, transported and dealt with at regular fridge temperatures (2-8 levels Celsius) for at the very least six months.
MODERNA

The mRNA vaccine by US-based firm Moderna has thus far been accepted to be used in Israel, the EU, Canada and the US.
A research of the efficacy of Moderna vaccine revealed it has 94.1 per cent efficacy in stopping the illness. In this sort of vaccine, the messenger RNA — or mRNA — acts as a blueprint for the manufacturing of the coronavirus spike protein and is encapsulated by lipid molecules and delivered into human cells. 
The cells of the vaccine recipient then use this mRNA genetic code to supply the viral protein to coach the immune system for a future encounter with the infectious coronavirus. 
Administered as two doses, 4 weeks aside, the Moderna vaccine can reportedly be saved within the fridge at 2-8 levels Celsius for as much as 30 days. At -20 levels Celsius it may be saved for as much as six months. This continues to be a problem for a lot of creating international locations within the tropical areas that have very excessive temperatures in the summertime months.
In November final yr, Moderna Chief Executive Stephane Bancel informed a German weekly that the corporate would cost governments between USD 25 and 37 per dose of its COVID-19 vaccine candidate, relying on the quantity ordered.
PFIZER-BIONTECH

The US-backed Pfizer-Biontech’s COVID-19 preventive, just like the Moderna vaccine, relies on the segments of the genetic materials of the novel coronavirus. Preliminary knowledge from the scientific trials confirmed that two doses of the vaccine, given three weeks aside, offered an efficacy of over 90 per cent.
Following the outcomes, the UK, Canada, the EU and Saudi Arabia have accepted the Pfizer vaccine to be used. Several international locations, together with the US, Singapore, Argentina and Mexico, have given emergency use authorisation.
One limitation for the Pfizer vaccine has been its requirement for ultracold storage — as much as -70  levels Celsius.
Each dose is reportedly priced at USD 37. 
SPUTNIK V

Sputnik V from Russia’s Gamaleya Research Institute has been accepted for emergency use by a number of international locations however awaits extra outcomes from Phase 3 trials.
An adenovirus vectored vaccine, Sputnik V is produced utilizing a mix of two adenoviruses known as Ad5 and Ad26. Preliminary proof from Phase 3 trials signifies it’s 90 per cent efficient when given as two doses, three weeks aside. 
In November, the Russian Direct Investment Fund stated the price of the vaccine could be lower than USD 10 per dose ranging from February 2021. It stated the dry type of the vaccine might be saved at 2-8 levels Celsius, and doesn’t want freeze storage.
CONVIDECIA

The adenovirus vectored vaccine developed by the Chinese firm CanSino Biologics can also be below Phase 3 trials and has already been accepted for restricted use by the Chinese navy.
Since August, the vaccine has been a part of Phase 3 trials in a number of international locations, together with Russia, Mexico and Pakistan.
CORONAVAC

Another Chinese firm, Sinopharm, has additionally made progress with its inactivated vaccine dubbed CoronaVac.
It has been given emergency approval for restricted use within the nation.
The vaccine is reportedly offered as two doses, administered two weeks aside.
Scientists are but to publish a research on the trial carried out thus far.
VECTOR INSTITUTE

Russia’s Vector Institute has developed a protein vaccine. It is presently below Phase 3 scientific trials.
It makes use of modified variations of the coronavirus spike protein to induce immunity.
The vaccine reportedly might be saved at 2-8 levels celsius for as much as two years.
Data on the efficacy of the therapeutic is but to be launched. 
NOVAVAX

After exhibiting promising leads to Phase 1-2 trials, and in animal experiments, the vaccine developed by US firm Novavax is presently below Phase 3 scientific trials.
It makes use of modified variations of the coronavirus spike protein to induce immunity, and may reportedly be saved at 2-8 levels Celsius.
After some setbacks in manufacturing the doses required for the Phase 3 research within the US, the trial was lastly launched on December 28.
JOHNSON & JOHNSON

The adenovirus vectored vaccine by the American firm has proven safety in opposition to the coronavirus in experiments in monkeys and is presently a part of Phase 3 scientific trials.
Unlike different vaccines, this vaccine is reportedly offered as a single dose, however trials are presently underway to check its efficacy as two doses.
The firm had famous that the therapeutic might be saved for as much as three months when refrigerated at 2-8 levels Celsius, and as much as two years when frozen at -20 levels Celsius. 
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